Entrada Therapeutics

Senior Manager, Clinical Supply Chain

Boston, MA
Full-time
$156,525 - $183,384
Posted Nov 13, 2026

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Skills

Communication
Google Cloud
Inventory Management
Operations
Project Management
Supply Chain
Teamwork

Job description

The Organization

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible. Through proprietary and versatile approaches, Entrada is advancing a robust development portfolio of genetic medicines for the potential treatment of neuromuscular and inherited retinal diseases, among others. Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne muscular dystrophy (DMD) who are exon 44, 45, 50 and 51 skipping amenable. Entrada has partnered with Vertex Pharmaceuticals to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1 (DM1).

2026 represents a catalyst-rich period for Entrada. We expect multiple clinical data readouts as we advance several DMD programs across the U.K., EU, and U.S. By year-end 2026, we anticipate four clinical-stage programs in our DMD franchise (ENTR-601-44, ENTR-601-45, ENTR-601-50, and ENTR-601-51). These programs are complemented by the ongoing clinical progress of our DM1 collaboration with Vertex (VX-670).

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Addition to Our Team

You are patient focused and excited about the opportunity to lead, establish, and execute the clinical supply functionality at Entrada. You enjoy a fast-paced environment and juggling competing priorities. You follow up and follow through, connecting problems with solutions efficiently. You work successfully in a team environment with strong interpersonal skills to effectively build working relationships inside and outside the company. 

The Opportunity

The Senior Manager, Clinical Supply Chain is an integral part of successfully executing Entrada’s clinical development strategy. This role ensures successful execution of clinical supply operations and partners cross-functionally to deliver uninterrupted clinical supplies for our global, multi-phase clinical trials.

Responsibilities

•Lead Entrada’s clinical supply chain activities, including label text generation, labeling and packaging operations, global distribution, inventory management, and IP reconciliation.

•Develop and maintain comprehensive supply plans aligned with clinical enrollment projections, dosing requirements, regulatory timelines, and clinical study milestones.

•Provide operational oversight of contract organizations involved in packaging, labeling, and distribution.

•Author, review, and approve clinical label text, multi-country clinical label designs, packaging batch records, pharmacy manuals, and clinical supply sections of study-related documents.

•Manage Investigational Product aspects of IRT systems including IRT specifications for study product, product availability and release status, shipment authorizations, and maintenance of study blind integrity.

•Develop appropriate supply risk mitigation strategies and proactively identify and manage risks related to study timelines, supply availability, expiry, inventory levels, and protocol updates.

•Partner with Quality and Clinical stakeholders to facilitate the timely review, approval, and execution of standard operating procedures, batch records, lot-release documentation, change controls, deviations, investigations, and corrective and preventive actions.

•Manage sourcing of ancillary supplies for IV infusion for clinical sites.

•Ensure adherence to applicable regulations, including FDA, EMA, ICH, GCP, GMP.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

•Humanity - We genuinely care about patients and about one another.

•Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.

•Creativity - We are creative problem solvers.

•Collaboration - We are more than the sum of our parts.

•Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

•Bachelor’s degree in supply chain, scientific or related field required with 8+ years of Clinical Supply Chain management in the pharmaceutical or biotechnology industry.

•Demonstrated experience planning and executing clinical supply strategies for complex, global clinical studies.

•Demonstrated experience managing clinical supply activities, including labeling, packaging, distribution, inventory management, product reconciliation, and forecasting.

•Experience supporting injectable programs requiring cold-chain storage and distribution.

•Demonstrated experience managing import and export activities for global clinical studies with a focus on North America and Europe.

•Strong operational and project management skills, with experience managing multiple programs, vendors, and deliverables simultaneously.

•Demonstrated proficiency working with 3 rd party IRT systems, including IP-related specification development.

•Experience overseeing Unblinded Clinical Supply activities, including management of site pharmacy inquiries and temperature excursions.

•Excellent communication (verbal and written) and interpersonal skills.

•Ability to exercise independent judgment with minimal supervision.

This is a US based remote position, with preference given to local New England based candidates. This role will require minimum quarterly travel to the Entrada Therapeutics Headquarters located in Boston, MA.

What We Offer: Meaningful Work, Fair Rewards, and Real Support

At Entrada Therapeutics, we understand that compensation and total rewards are a major consideration when exploring a new opportunity. We believe in transparency and equity and are committed to sharing salary ranges for every position, along with insight into our compensation philosophy, in accordance with certain state requirements in the United States and fostering a fair and open environment at the onset.

But we also know it is more than just pay. When you join Entrada, you’ll be part of a mission-driven team with access to comprehensive health, dental and vision coverage; life and disability insurance; with a 401(k) match. We pride ourselves on offering competitive benefits that empower our employees and reflect the value of their contributions – offering paid, gender-inclusive parental leave, holistic support for your health and well-being, education reimbursement, discretionary time off and commuting benefits aligned to your working model. If you find yourself working from our office in Boston’s Seaport District, this puts you steps away from some of the best the city has to offer.

At Entrada, our approach to compensation is grounded in transparency, equity, and performance, recognizing the unique contributions each person brings. We believe meaningful work deserves meaningful reward, and view compensation as one way to show appreciation for the collaboration, curiosity, and commitment that drive our mission forward.

The salary for this opportunity ranges from $156,525 - $183,384. The final base compensation offered will depend on several considerations which include but may not be limited to a candidate’s skills, competencies, experience and other job-related factors permitted by law. The final salary offered may fall outside of this range. #LI-JF1 #LI-Remote

Pay transparency

$156,525 — $183,384 USD

Equal Opportunity Employer

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law. 

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

Privacy Statement

Entrada Therapeutics, Inc. (the “ Entrada ,” “ we, ” “ us, ” or “ our ”) respects your privacy and we want you to be familiar with how we collect, use, share, or otherwise process, your Personal Information. Please reference our privacy statement here to understand how and when your data is being used.